Iron dextran Chloramphenicol

The absorption of oral iron is decreased when tlie agent is administered with antacids, tetracyclines, penicillamine, and the fluoroquinolones. When iron is administered with levothyroxine, there may be a decrease in tlie effectiveness of levothyroxine When administered orally, iron deceases the absoqition of lev-odopa. Ascorbic acid increases tlie absoqition of oral iron. Iron dextran administered concurrently with chloramphenicol increases serum iron levels. 

WARNING Anaphylactic Rxns w/ use use only if oral Fe not possible administer where resuscitation techniques available Uses Fe deficiency when cannot supl PO Action Fe supl Dose Adul. Iron defic anemia Estimate Fe deficiency, give 25-100 mg IM/IV /d until total dose total dose (mL) = [-.0442 x (desired Hgb - observed Hgb) x LBW] + (0.26 x LBW) Iron replacement, blood loss Total dose (mg) = blood loss (mL) x Hct (as decimal fraction) max 100 mg/d Peds >4 mo. As for adults max 0.5 mL (wt <5 kg), 1 mL (5-10 kg), 2 mL (>10 kg) p dose IM or direct IV Caution [C, M] Contra Anemia w/o Fe deficiency. Disp Inj SE Anaphylaxis, flushing, dizziness, inj site inf Rxns, metallic taste Interactions X Effects W/ chloramphenicol, X absorption of oral Fe EMS Anaphylactic Rxns common taking oral Fe t risk of tox and SEs OD May cause N/V, HA, muscle/joint pain and fev symptomatic and supportive Iron Sucrose (Venofer) [Iron Supplement] Uses Fe deficiency anemia w/ chronic HD in those receiving erythropoietin Actions Fe r lacement. Dose 5 mL (100 mg) IV on dialysis, 1 mL (20 mg)/min max Caution [C, M] Contra Anemia w/o Fe deficiency Disp Inj SE Anaphylaxis, -1- BP, cramps, N/V/D, HA Interactions i Absorption OF oral Fe supls EMS See Iron Dextran OD See Iron Dextran... 

Ten out of 22 patients receiving iron dextran for iron-deficiency anaemia and also given chloramphenicol, failed to show the expected haematological response to the iron. Four patients receiving vitamin B]2 for pernicious anaemia were all similarly lefiactory to treatment until the chloramphenicol was withdrawn. ... 

Chloramphenicol can cause two forms of bone marrow depression. One is serious and irreversible, and can result in fatal aplastic anaemia, whereas the other is probably unrelated, milder and reversible, and appears to occur at chloramphenicol serum levels of 25 micrograms/mL or more. This occurs because chloramphenicol can inhibit protein synthesis, the first sign of which is a fall in the reticulocyte count, which reflects inadequate red cell maturation. This response to chloramphenicol has been seen in animals healthy individuals, a series of patients with liver disease," and in anaemic patients being treated with iron dextran or vitamin Bj2. 

Aminosalicyclic acid, bacitracin, blood plasma, blood serum, methicillin salts, culture media, dextran, enzymes, gamma-globulin, hormones, streptomycin, iron dextran, lysine, casein hydrolysate, penicillin, serum hydrolysate, penicillin, serum hydrolysate, tetracycline vitamins, oleandomycin, chloramphenicol succinate salts... 

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