Chitosan water-soluble system

Chitosan Water-Soluble System An Approach to Prepare Superabsorbent Gel... 

Previously, we clarified the complexation of chitosan with hydroxybenzo triazole, resulting in a water soluble system of chitosan (27-25). The system is attractive since it provides the reaction, and especially the conjugation, in aqueous media. Based on this approach, the present work, thus, (i) demonstrates a simple but effective crosslink reaction by using poly(ethylene glycol) as the crosslinker to obtain a superabsorbent gel in aqueous, and (ii) proposes... 

Another polysaccharide system that has received considerable interest is the chitosans which are water soluble derivatives of chitin. These materials appear to be very biocompatible and degradable and so are potentially excellent candidates as polymeric drug systems (27). 

Bernkop-Schnurch A, Humenberger C, Yalenta C (1998) Basic studies on bioadhesive delivery systems for peptide and protein drugs. Int J Pharm 165(2) 217-225 Chae SY, Jang M-K, Nah J-W (2005) Influence of molecular weight on oral absorption of water soluble chitosans. J Control Rel 102(2) 383-394 Cho EC, Lim HJ, Shim J, Park JY, Dan N, Kim J, Chang I-S (2007) Effect of polymer characteristics on structure of polymer-liposome complexes. J Colloid Interf Sci 311(1) 243-252... 

The advantage of ehemical derivatives has always been their solubility potential. This ability alone lends the biomaeromolecule to more thorough chemical characterization, for example, molecular weight determination by GPC, poorly achieved with chitin and challenging with chitosan. The use of lower moleeular weight materials would alleviate the situation somewhat, but truly soluble systems especially in water would transform the evaluation of these biopolymers that is vital for biomedical applications. Coupled with the potential for new desirable properties a chanical derivative can provide, this aspect wiU increasingly attract attention. 

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