Chitin Candida albicans

Surarit R, Gopal PK, Shepherd MG (1988) Evidence for a glycosidic linkage between chitin and glucan in the cell wall of Candida albicans. J Gen Microbiol 134 1723-1730... 

Chiew, Y.Y., Shepherd, M.G. Sullivan, P.A. (1980) Regulation of Chitin Synthesis During Germ-tube Formation in Candida albican. Archives of Microbiology, 125, 97-104 Cohen, R.E., Zhang, W-J. Ballou, C.E. (1982) Effects of Mannoprotein Mutations on Saccharomyces cerevisiae Core Oligosaccharide Structure , Journal of Biological Chemistry, 257, 5730-7... 

In the discovery of new antifungal compounds, Tsukuda and coworkers synthesized a nikkomycin analog library by Ugi condensation of uridine derivative 84, 59 carboxylic acids 85, 15 isocyanides 86, and an amino component attached to a Rink amide resin 87 (Figure 11.43). After cleavage from solid support, compounds 88 were tested for the enzyme inhibitory activity against Candida albicans chitin synthase 1. Among these derivatives, 246 samples exhibited more than 50% inhibition against this enzyme at a concentration of 10 tg/ml. 

The association of chitin, D-glucan, and D-mannan in the cell walls of Candida albicans and the spatial distribution of these polysaccharides have been found to vary appreciably between two dimorphs and with the age of the culture. ... 

---