Chirality homogeneity of biomolecules

ASYMMETRIC AUTOCATALYSIS WITH AMPLIFICATION OF CHIRALITY AND ORIGIN OF CHIRAL HOMOGENEITY OF BIOMOLECULES... 

Shibata T, Morioka H, Hayase T, Choji K, Soai K (1996) Highly enantioselective catalytic asymmetric auto-multiplication of chiral pyrimidyl alcohol. J Am Chem Soc 118 471-472 Soai K, Kawasaki T (2006) Discovery of asymmetric autocatalysis with amplification of chirality and its implication in chiral homogeneity of biomolecules. Chirality 18 469-478 Szostak JW (2010) On the origins of primitive cells from nutrient intake to elongation encapsulated nucleotides. Angew Chem 49 3738-3750 Szostak JW et al (2001) Synthesizing life. Nature 409 387-390... 

Soai K, Kawasaki T Discovery of asymmetric autocatalysis with amplification of chirality and its implication in chiral homogeneity of biomolecules. Chirality 2006, 18(7) 469-478. 

Soai, K. Kawasaki, T. Discovery of Asymmetric Autocatalysis with Amplification of Chirality and Its Implications in Chiral Homogeneity of Biomolecules. Chirality 2006, 18, 469. 

Hybrid catalysis is a concept that combines biocatalysis with homogeneous chemical catalysis. Typically, a chemical catalyst (most often a transition-metal complex) is anchored inside a pocket of a biomolecule, and, according to the original concept, the metal complex should provide the reactivity while the chiral environment of the biopolymer determines and fine-tunes the selectivity. Meanwhile, several systems have been developed where such a clear-cut distribution of work is not possible anymore and the biomolecule contributes significantly to rate acceleration. 

Alfred Werner conjectured as early as 1899 that octahedrally coordinated metal complexes should occur in nonidentical minor image isomers. For such objects. Lord Kelvin, in 1893, had coined the adjective chiral , a term never used by Werner. It can be proved by examination of the original sample of [Co(NC)2)2(en) Br, prepared by Edith Humphrey, a Ph.D. student of Wemer s, that crystals of optically pure samples were obtained in Werner s laboratory as early as 1899 or 1900. However, Werner did not publish die first successful resolution of an octahedral metal complex until 1911. Presently, interest in chirality in coordination compounds is booming, mainly because of the importance of coordination compounds in enantioselective homogeneous catalysis. Other interesting sq )plications are enantioselective interactions of chiral coordination species with biomolecules, and the stereoselective synthesis of multicenter systems. 

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