Chiral Separations by Nanoliquid Chromatography and Nanocapillary Electrophoresis

CHIRAL SEPARATIONS BY NANOLIQUID CHROMATOGRAPHY AND NANOCAPILLARY ELECTROPHORESIS 

Due to the importance of chiral drugs and pharmaceuticals, Witte et al. [7] and Rauws and Gioen [8] reviewed the status of regulatory aspects of chiral medicinal products in the pharmaceutical industries of the United States, Japan, and some European countries. The U.S. Food and Drug Administration (FDA) and other 

Nanochromatography and Nanocapillary Electrophoresis. By Ali, Aboul-Enein, and Gupta Copyright 2009 John Wiley Sons, Inc. 

In environmental science chirality has an important role as degradation of some achiral pollutants result in chiral toxic metabolites. Therefore, predicting the exact toxicities of the pollutant concentrations of both enantiomers is required and essential. For example, two enantiomers of a-hexachlorocyclo-hexane pesticide have different toxicities. Moreover, the rates of degradation of the enantiomers of a-hexachlorocyclohexane are also different [9,10]. 

Pumera and coworkers [17] used nano-HPLC for enantiomeric resolution of ephedrine, pseudoephedrine, and ibuprofen by using (3-cyclodextrin as chiral 

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