Chiral recognition three-attachment model

Figure 15 Deformation of the surface for chiral recognition, (a) A three-point attachment model for enantioresolution on the surface (b) a surface with a shallow dip (c) a surface with a steep dip and (d) a channel in the extreme case, caused by deformation.

The three-point attachment rule is largely qualitative and only valid with bimolecular processes (e.g., small Pirkle or ligand-exchange selectors). Another drawback of this model approach is that it cannot be applied to enantiomers with multiple chiral centers. Sundaresan and Abrol [15] proposed a novel chiral recognition model to explain stereoselectivity of substrates with two or three stereo centers requiring a minimum of four or five interaction points. In the same way, Davankov [16] pointed out that much more contact points are realized with chiral cavities of solids. 

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