Chiral recognition molecule Subject

HSA bears structural and functional resemblance to BSA, and HSA-type CSPs [164] also show similar enantioselective binding preferences for acidic and neutral drug molecules, such as 2-aryloxypropanoic acids [165], warfarin [166] and benzodiazepines [167]. The chiral recognition mechanism of HSA has been the subject of a number of investigations [168], which revealed that enantioselective binding occurs primarily at two well-defined hydrophobic sites. Acidic drugs have been shown to bind preferentially to the so-called warfarin-azapropazone (site I) and neutral drugs to the indol-benzodiazepine site (site II). 

The recognition of chiral carbonyl compounds, especially the substrates having a chiral stereogenic center at the a-carbon, have been a main subject of research for long time [81], since Curtin [82] and Cram [83] initially proposed a structural model for the diastereoselective addition to these molecules. There are in-depth studies related to this subject including chiral enolate addition, i.e., double asymmetric synthesis [84]. In this section, therefore, some other impressive topics of current interest are discussed briefly. 

The chiral molecular recognition of neutral molecules has become an important subject in the fields of analytical, biochemical and pharmaceutical technologies. 

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