Chiral MIP Applications

Various publications have already described MIP-modified sensors, which showed good chiral recognition toward the enantiomers of different amino acids. The feasibility of achieving electrosynthesized polyacrylamide membranes imprinted with L- or D-His was explored by using AC impedance spectroscopy and 

The enantiomers of phenylalanine anilide were analyzed on an imprinted poly(EDMA-co-MAA] polymer grafted onto an ITO glass electrode based on the chiral discriminative gate effect of the MIP in organic solvents [49]. The chiral differentiation implied the evaluation of the effect of phenylalanine anilide enantiomers on the faradic current of redox species (ferrocene], effect caused by a 

Self-assembled monolayer and layer-by-layer approaches were combined by thermal cross-linking on the surface of a silver electrode in order to develop a MIP-based sensor for the chiral analysis of thyroxine, a thyroid hormone with an amino-acid side chain [53]. The DPASV response peak current was linear to the concentration of thyroxine in the range from 0.010 to 17.2 ng mL and the achieved detection limit was 0.0060 ng mL. The molecularly Imprinted film displayed absolute enantioselectivity to the template enantiomer and was applied for the determination of thyroxine in aqueous, blood and pharmaceutical samples with no interference from related compounds. 

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