Chiral binol derived bifunctional amine

Chiral Binol-Derived Bifunctional Amine Catalysts... [Pg.408]

Aromatic ketimines are reduced enantioselectively to amines (50 atm H2/toluene/65°C/24h), using a cooperative catalysis involving Knolker s iron complex and a BINOL-derived hydrogen phosphate auxiliary, with P-NMR evidence supporting the bifunctional catalysis. A phosphine-free chiral cationic ruthenium complex catalyses enantioselective hydrogenation of IV-alkyl ketimines, including many heretofore problematic substrates. 0... [Pg.13]

Asymmetric addition of diorganozincs to aldehydes and ketones has been reviewed, focusing on bifunctional catalysts such as those prepared from salens or BINOLs. Regioisomeric chiral amine-sulfonamide organocatalysts give >99% yield and up to 98% ee in addition of diethylzinc to aldehydes. Switching between regioisomers effectively switches the direction of selectivity. Amino-acid-derived (15,l 5)-4,4 -biquinazoline primary amines catalyse ethylation of aryl aldehydes in up to 95%... [Pg.39]

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