Chiral amine synthesis

Another field where ATH catalysts have made an industrial impact is in the area of chiral amine synthesis by stereocontrolled reduction of imines. First demonstrated by Uematsu et the reduction of cyclic imines to yield chiral amines... 

Figure 1.39 Chiral amine synthesis using modified boranes.

Cleavage of hydrazines. Hydrogenolysis follows addition of alkyllithiums to SAMP/RAMP hydrazones in chiral amine synthesis (13 examples, 41-73%). 

Reznichenko AL, Hultzsch KC (2010) In Nugent TC (ed) Chiral amine synthesis methods, developments and applications. Wiley, Weinheim, p 341... 

Chiral Amine Synthesis Methods. Developments and Applications. Edited by Thomas C. Nugent Copyright 2010 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-32509-2... 

The enantioselective reductive amination of ketoacid substrates has been dem onstrated and provides amino acids that are beyond the scope of this review [6]. Enzymatic based reductive amination is now possible and allows nonamino acid chiral amine synthesis, however, this field of study is also beyond the scope of this material [7]. Finally, much of the material discussed here also appeared in a recent review of ours on the general subject of chiral amine synthesis. 

Substrate-Controlled Chiral Amine Synthesis via C H Amination... 

Chiral Amine Synthesis —Strategies, Examples, and Limitations... 

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