Children hyperthyroidism

A 3-year-old child, whose mother had been treated for Graves hyperthyroidism with thiamazole throughout pregnancy, had two scalp lesions and other abnormalities of tissues of ectodermal origin, including dystrophic nails and syndactyly. 

Neonatal hypothyroidism has been reported after maternal use of antithyroid drugs (106,107). Transient neonatal hyperthyroidism in a female child born to a mother who had been treated with potassium iodide and carbimazole during pregnancy was followed by sexual precocity (108). 

Domenech E, Santisteban M, Moya M, Gonzalez C, Cortabarria C, Mendez A, Alvarez J, Rodriguez-Luis JC. Hipertiroidismo neonatal transitorio e hijo de madre hipertiroidea tratada. Posterior aparicion de precocidad sexual. [Transient neonatal hyperthyroidism in the child of a treated hyperthyroid mother. Subsequent appearance of sexual precocity.] An Esp Pediatr 1985 22(4) 281-7. 

Spurious hyperthyroidism occurred in a child taking thyroid hormone and imipramine for enuresis (89). The ability of thyroid hormone to increase receptor sensitivity to catecholamines has long been known, and has been used to enhance the clinical response in some refractory patients, especially women. 

Karpathios T, Zervoudakis A, Thodoridis C, et al. 1991. Mercury vapor poisoning associated with hyperthyroidism in a child. Acta Paediatr Scand 80(5) 551-552. 

Dose For hyperthyroidism in adults, initially 200 to 300 mg per day in 3 divided doses when the patient attains normal basal metabolic rate (euthyroidism) the dose is usually reduced to a maintenance dose fo 50 to 75 mg daily in 2 to 3 divided doses. In children over 10 years old, initial, 150 to 300 mg per day in 4 divided doses until the child becomes euthyroid, then usually 100 mg daily in 2 divided doses, for maintenance. 

Barrington et al., (1999) Hyperthyroidism 195-800 For 3-6 weeks use of thermoluminescence dosimeters on wrists of family members. Avoid close contact with other individuals following standard procedures from five hospitals in the United Kingdom advice A and B differed according to administered activities advice B was also dependent on the age of the child. 

---