Children drug elimination

Susceptibility factors Genetic A 5-year-old child died after being given hydrocodone bitartrate 1 mg/ml, 1 teaspoon tds [97" ]. Genetic analysis showed that the child had reduced ability to metabolize hydrocodone via CYP2D6. Co-administration of clarithromycin and valproic acid had further reduced drug elimination, leading to accumulation of lethal concentrations. 

Today, most pediatric dosages are clearly given by the manufacturer, tiius eliminating die need for formulas, except for determining die dose of some drugs based on die child s weight or BSA. 

Are there any reports or studies on the clinical outcome in nursing children What effects could be expected in the infant How can the infant or child eliminate the drug ... 

One elimination route that is of importance to a specific type of patient is breast milk. Nursing mothers must be very careful when taking medication because many drugs are eliminated, at least partially, through breast milk. A mother may unintentionally serve as a drug administration vehicle for her nursing child. 

---