ChemScore consensus scoring

The calculation of the binding affinity with con.sidcration of all tbc.se effects for virtual screening is not possible. In order to circumvent thus difficulty, scoring functions arc used instead, c.g., the Liidi scoring function [80, or consensus scoring functions derived from FlevX score, DOCK score, GOLD score, ChemScore, or PMF score [81 ]. 

Chemscore Cscore Regression-based scoring function Suite of scoring functions (ChemScore, DOCK, FlexX, GOLD, PMF) and consensus scoring tool... 

A list of the most common and most recent empirical scoring functions described in the literature is provided in the Appendix (Appendix A Sofiware Overvie v, Section Scoring functions ). It should be noted that some of the functions listed there exist in different software implementations (as, for example, ChemScore). Furthermore, a single name may represent multiple function variants developed by the same authors (as, for example, in the case of X-Score and SFCscore). The list also includes functions that contain force field terms, but since these are multiplied by a weighting coefficient calibrated on experimental affinities, the functions should be classified as empirical (occasionally, they are referred to as semiempirical scoring functions). Finally, some of the functions (e.g., ScreenScore) follow a consensus scoring approach (as discussed in detail in Section 7.4.3), which means that the ultimate score is obtained from the combined application of at least two functions. 

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