Malaria, chemotherapy

W. Peters and W. H. G. Richards, eds., MntimalarialDrugs, Vols. 1 and 2, Springer-Vedag, New York, 1984 L. J. Bmce-Chwatt, ed. Chemotherapy of Malaria, WHO, Geneva, Switzedand, 1981 Practical Chemotherapy of Malaria, WHO Technical Report 805, 1990. 

In malaria chemotherapy, resistant parasites have significantly reduced the efficiency of classic antifolate drugs. In the search for novel inhibitors of... 

The primary reasons why travelers are infected with malaria are failure to take chemotherapy, inappropriate chemotherapy, and delay in seeking medical care. 

Key Natural Products in Malaria Chemotherapy From Quinine to Artemisinin and Beyond... 

In this chapter, we discuss the important role played by some key natural products in malaria chemotherapy. We focus on naturally occurring secondary metabolites that had substantially affected the control and treatment of malaria. Advances in the total synthesis of these compounds and derivatives, and their implications in new strategies for the development of new generation of antimalarial drugs are also discussed. 

Some Key Natural Products in the Malaria Chemotherapy 2.1. Quinine and Derivatives... 

It is clear that no other compound or family of compounds have affected the chemotherapy of malaria as much as quinine and its derivatives, and artemisinin and its derivatives. Nevertheless, there are some classes of natural products that have made it to the market or at least at the advanced stage of clinical trials as antimalarial. Among them are quinones, chalcones and xanthones. 

Hempelmann E, Tesarowicz I, Oleksyn BJ. (2009) Short history of malaria chemotherapy. Pharm Unserer Zeit 38 500-507. 

It is used for all types of malaria, for chemotherapy, as well as for non-gastric amebiasis, and amebic abscesses of the liver. Synonyms of this drug are nivaquine, quingamine, delagil, resoquine, atroquine, and others. 

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