Chemotherapy-induced neuropathic pain

Lynch, J. J. 3rd, Wade, C. L., Zhong, C. M., Mikusa, J. P., and Honore, P. (2004). Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model. Pain 110, 56—63. 

Observational studies In an open study in 75 patients with chemotherapy-induced neuropathic pain, gabapentin monotherapy 800 mg/day caused mild somnolence in about 25%, but none stopped taking the drug [106 =]. 

Tsavaris N, Kopterides P, Kosmas C, Efthymiou A, Skopelitis H, Dimitrakopoulos A, Pagouni E, Pikazis D, Zis PV, Koufos C. Gabapentin monotherapy for the treatment of chemotherapy-induced neuropathic pain a pilot study. Pain Med 2008 9(8) 1209-16. 

A 12-year-old boy with prostatic rhabdomyosarcoma had episodes of syncope periodically over 7 months while taking fluconazole for chemotherapy-induced mucositis. He had taken fluconazole in the past without problems but had also taken a stable dose of amitriptyline for neuropathic pain. On withdrawal of amitriptyline he had no further episodes. The effect was confirmed by re administration. 

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