Chemotherapy dosage levels

In substantiation, Dr. Yurkovsky cites the well-known law of pharmacology, called the Arndt-Schultz law, that low doses excite physiological activity, moderate doses favor it, but high doses retard or arrest it. An analogy is to Le Chatelier s principle, that chemical systems at equilibrium tend to resist imposed external effects. Further, there are the observations of Dr. Denis Parsons Burkitt, discoverer of Burkitt s lymphoma, about chemotherapy dosage levels. His viewpoint was that smaller is better (possibly serving to stimulate the immune system). It is a protocol favored in Britain but not in the United States. 

It can be further remarked that, at Pauling s insistence, vitamin C was once tested on terminal cancer patients at the Mayo Clinic and found ineffective. Pauhng s rebuttal was that the patients had previously been subjected to chemotherapy, which destroyed their immune system. (The debilitating effect of chemotherapy on the immune system is now part of medical folklore.) In response, a second testing was conducted on patients who had not been previously treated with chemotherapy. The results again were that the vitamin C so administered was not effective. In common with other quandaries, the dehnitive resolution and answer await. There are such matters to be clarified as methods of administration, dosage levels, frequency, length of treatment, and bias. 

At slightly higher or somewhat higher dosages, to be determined, there is also the possibihty that a suitably poisonous plant substance will selectively and directly attack the cancer cells. This type of plant-derived chemotherapy is presumably the role of the HCN released from laetrile. These are the situations where dosage levels become critical, so that the effect is not overdone or underdone. A problem for consideration is its effectiveness in certain people and not in the others. There is also the thought that the doses could perhaps be tailored to suit individuals. 

To prevent uric acid nephropathy during chemotherapy PO Initially, 600-800 mg/day starting 2-3 days before initiation of chemotherapy or radiation therapy. IV 200-400 mg/mVday beginning 24-48 hr before initiation of chemotherapy. Akrt Maintenance dosage is laased on serum uric acid levels. Discontinue following the period of tumor... 

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