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Chemotherapeutic agents cytotoxic action

Based on this pathway of cell death, it appears likely that agents which can alter NAD or ATP metabolism should be useful in sensitizing cells to the cytotoxic effects of some chemotherapeutic agents whose mechanism of action involves the production of DNA damage. Both 6-aminonicotinamide (6-AN) and Tiazofurin (Taz) have already been shown to interfere at multiple steps of pyridine nucleotide metabolism. Taz has been shown to produce the Taz analog of NAD (8, 9), to interfere with NAD synthesis and... [Pg.368]

See other pages where Chemotherapeutic agents cytotoxic action is mentioned: [Pg.433]    [Pg.445]    [Pg.159]    [Pg.269]    [Pg.187]    [Pg.339]    [Pg.389]    [Pg.427]    [Pg.173]    [Pg.162]    [Pg.269]    [Pg.102]    [Pg.28]    [Pg.1138]    [Pg.390]    [Pg.39]    [Pg.637]    [Pg.150]    [Pg.367]    [Pg.403]    [Pg.50]    [Pg.39]    [Pg.211]    [Pg.2176]    [Pg.146]    [Pg.211]    [Pg.146]    [Pg.286]    [Pg.2]    [Pg.252]    [Pg.858]    [Pg.5484]    [Pg.234]    [Pg.511]    [Pg.5483]    [Pg.211]    [Pg.2112]    [Pg.400]    [Pg.935]   
See also in sourсe #XX -- [ Pg.1138 ]



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