Chemokines lymphocyte homing

Campbell JJ, Butcher EC Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 2000 12 336-341. 

Gunn, M. D., Kyuwa, S., Tam, C., Kakiuchi, T., Matsuzawa, A., Williams, L. T., and Nakano, H. (1999). Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451-460. 

It is still unclear which chemokines and chemokine receptors facilitate the homing of T lymphocytes to the lymph nodes of the lung. Research thus far has focused on T lymphocyte homing to peripheral lymph nodes, which are more easily accessible for dissection and study. It is only recently that the chemokines and chemokine receptors responsible for T-lymphocyte homing to the alveoli, lung parenchyma, or lymph nodes of the lung have been investigated. 

After maturation in the bone marrow, B lymphocytes home into secondary lymphoid tissues, such as lymph nodes, from which they are soon released into the circulation, or move through different areas while undergoing a final differentiation (3). The chemokine receptor CXCR5 may be involved in B-lymphocyte entry into the B-lymphocyte-rich follicles. CXCR5 is expressed on the surface of mature circulating B lymphocytes (3,35,60). Its ligand, CXCL13, is constitutively expressed within the follicles (2,3,61). 

Brune W, Menard C, Heesemann J, Koszinowski UH (2001) A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism. Science 291 303-305 Campbell JJ, Butcher EC (2000) Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 12 336-341... 

Tsuboi, K., Hirakawa, J., Seki, E., Imai, Y., Yamaguchi, Y., Fukuda, M., et al. (2013). Role of high endothehal venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing. Journal of Immunology, 191(1), 448 55. http //dx.doi.org/ 10.4049/jimmunol.l203061. 

Giagulli C, Scarpini E, Ottoboni L, et al. RhoA and PKCzeta control distinct modalities of LFA-1 activation by chemokines critical role of LFA-1 affinity triggering in lymphocyte in vivo homing. Immunity 2004 20(l) 25-35. 

Fibroblastic reticular cells (FRCs) constitute the main stromal population and form its internal three-dimensional network. FRCs express surface molecules and produce homing chemokines for T cells, B cells, and DCs. FRCs provide anatomical airangements that influence the riaffic patterns of lymphocytes facilitating lymphocyte crawling along pre-... 

Lopez-Giral, S., N. E. Quintana, M. Cabrerizo, M. Alfonso-Perez, M. Sala-Valdes, V. G. De Soria, J. M. Fernandez-Ranada, E. Fernandez-Ruiz, and C. Munoz. 2004. Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. J Leukoc Biol 76 462-471. 

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