Chemokines discovery

The rapid pace of chemokine discovery led to a nomenclature crisis, especially in the naming of chemokine ligands. Early reports assigned multiple names to the same chemokine. Fortunately, a new standardized nomenclature has been adopted, largely based on a system previously used for naming of chemokine receptors. Specifically, chemokine receptors are referred to as CC (in the case of the CC chemokine family), CXC (for the CXC family), C (lymphotactin/... 

Novel Chemokines Discovery and Genetically Engineered Mice... 

Central tendency, 226-227 Chemical genomics, 178 Chemical tools, in target-based drug discovery, 178-179 Chemokine C receptor type 1, 133 Chemokine receptors, 6, 44, 53, 129, 132, 177... 

Discovery of Chemokine Receptors as Second Receptors for HlV-1 Infection... 

TM) GPCRs, and the identification of these two molecules facilitated the discovery of many of the other chemokine receptors. The identification of the two IL8 receptors was followed, shortly after, by the cloning of a receptor for CC chemokines. This receptor was initially called CC-CKR1 (now CCR1) and was shown to promiscuously bind a number of members of the CC chemokine family (6). Subsequent to the identification of these three chemokine receptors, two principal methods have been used to clone the cDNAs for the other currently identified receptors ... 

Godessart N. Chemokine receptors attractive targets for drug discovery. Ann N Y Acad Sci 2005 1051 647-657. 

Terricabras E, Benjamim C, Godessart N. Drag discovery and chemokine receptor antagonists eppur si muove Autoimmun Rev 2004 3(7-8) 550-556. 

Bhalay G, Dunstan A. Chemokine Receptors and Drug Discovery—SMR meeting. 11 March 2004, Horsham, UK. IDrugs 2004 7(5) 441-443. 

Key Words Chemokine receptor drug discovery in vitro assay. 

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