Chemokine effector cells attracted

Delgado M, Gonzalez-Rey E, Ganea D, VIP/ PACAP preferentially attract Th2 effectors through differential regulation of chemokine production by dendritic cells. FASEB J. 2004. 18, 1453-1455. 

At a later stage of CMV infection, local inflammatory reactions could be controlled by chemokine downregulation around the infected cells. The pUS28 receptor adsorbs RANTES from the infected cell environment (Billstrom et al. 1999 Bodaghi et al. 1998). RANTES, as well as MIP-lot/p and MCP-1 and 3, which also bind pUS28, are chemoattractant for T, dendritic, and natural killer cells (reviewed in Loetscher et al. 2000). RANTES adsorption by pUS28 could inhibit establishment of a chemokine gradient and thereby block both lymphocyte attraction and effector mechanism activation (Hadida et al. 1998). 

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