Chemistry solubility

Aqueous solubility is typically inversely proportional to lypophilicity. Lypophilicity represents the affinity of a molecule (or moiety) for a lypophilic environment. Dmg solubility is also an important attribute to its oral absorption and subsequent permeability through membranes. In medicinal chemistry, solubility for a 1-mg kg dose of 5,50, and 500 p,g mL is estimated to be low, medium, and high, respectively (Van de Waterbeemd, 2002). Solubility characteristics have long been recognized as important in pharmaceutical chemistry and are part and parcel of the drug design process. For example, the solubility can be used to determine the maximal absorbable dose (MAD), that is. 

Grant, D. J. W. Higudri, T. Techniques in Chemistry Solubility of Organic Compounds, Wiley New York, 1990. 

Moldulate/tuning of properties via chemistry Solubility and processibility Large polarizability of constituent molecules Low environmental contamination Potential biocompatibility Photomagnetic effects... 

Fossil fuel compound biogeochemistry research needs range from bench chemistry solubility studies to studies of global transport phenomena for the atmosphere and oceans. 

The values in this table are taken almost exclusively from the International Union of Pure and Applied Chemistry Solubility Data Series . Unless noted, they comprise evaluated data fitted to a smoothing equation. The data at each temperature are then derived from the smoothing equation which expresses the mole fraction solubility of the gas in solution as ... 

Kester, D.R., O Conner, T.P. and Byrne, R.H. Jr., 1975a. Solution chemistry, solubility and adsorption equilibria of iron, cobalt and copper in marine systems. Thaiassia Yugosl., 11 121—134. 

Pillai, C.K.S., Paul, W., Sharma, C.P. Chitin and chitosan polymers Chemistry, solubility and fiber formation. Prog. Polym. Sci. 34, 641-678 (2009)... 

Pillai CKS, Paul W, Sharma CP (2009) Chitin and chitosan chemistry, solubility, and fiber formation. Prog Polym Sci 34 641-678... 

Introduction to Applied Colloid and Surface Chemistry solubility parameters (dispersion, polar, hydrogen... 

In coordination chemistry solubility is an important property that determines whether a complex will remain in solution (which foustratingly occurs during many attempts to isolate a solid) or will precipitate as a solid (which likewise occurs during many attempts to generate a solution). The eternal problem of the solubility of chemical compounds has not yet been solved completely. Our analysis of the current state-of-the-art in solubility, as it relates to synthetic coordination chemistry, is given in Chapter 2. 

Pillai, C. K. S., WiUi Paul., Chandra., Sharma, P. Chitin and chitosan polymers. Chemistry, solubility and fiber formation Progress in Polymer Science. 2009, 34,... 

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