Chemistry on Solid Phases

The initial report on solid-phase synthesis appeared in 1963, when Merrifield [1] developed a way to make peptides by solid-phase synthesis. Since then the general field of solid-phase organic synthesis (SPOS) has grown enormously. The fundamental technique is based on polymeric resin beads to which a reactant is covalently bonded (Fig. 2.3-1). 

Several advances have been made in the field of SPOS, notable among them the concepts of parallel synthesis and divergent synthesis [2]. These strategies permit the rapid production of large collections of compounds. Also new technologies ha- 

Green Separation Processes. Edited by C. A. M. Afonso and J. G. Crespo Copyright 2005 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 3-527-30985-3 

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M-L Valero, E.Giralt, D Andreu. Optimized Asp/Glu side chain anchoring in synthesis of head-to-tail cyclic peptides by Boc/OFm/benzyl chemistry on solid phase, in R Ramage, R Epton, eds. Peptides 1996. Proceedings of the 24th European Peptide Symposium, Mayflower, Kingswinford, 1998, pp 857-858. 

Cargill IF, Maiefski RR, Toyonaga BE, Automated combinatorial chemistry on solid phase, In Proceedings of the International Symposium on Laboratory Automation and Robotics, 1995, Zymark Corporation, Zymark Center, Hopkinton, MA, pp. 221-234, 1995. 

Cargill JF, Maiefski RR, Automated combinatorial chemistry on solid phase, Lab Robotics Automation, 8 139-148, 1996. 

Abstract This review covers recent advances in the field of radical chemistry on solid phase. Intermolecular processes using both immobilized radicals with solution-phase acceptors and immobilized acceptors with radicals in solution are discussed, as are radical cyclization reactions on polymer supports. Progress in the development of solid-phase asymmetric radical processes and the design of linkers cleaved by radical processes are also discussed. 

Boc group has been used in the Fmoc/tBu chemistry on solid phase for semipermanent N -protection (Section 4.3.2.2).t °l... 

Products/technologies For automation of combinatorial chemistry on solid phase in a modular approach, the OntoBlock central piece of hardware consists of 96 2-ml polymeric reaction vessels containing beads on which the synthesis takes place. From there the test components are stored, are characterized, or... 

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