Chemical relaxations of ligand binding and recognition

3 Chemical relaxations of ligand binding and recognition Rai e of applications 

Extending the range of examples of expressions for relaxation times for alternative and more complex pathways is easily carried out by the algebraic methods presented above. The difficulties arise in the experimen- 

The clockwise pathway and its concentration dependence is described at the end of the last section. The anti-clockwise pathway, which involves the pre-equilibrium of a protein conformation change was treated by Halford (1972) in terms of the simplified scheme  

Using the procedure of section 6.2 to derive the relaxation equations, the following expressions for the sum and the product of the reciprocal relaxation times are obtained. 

If the relaxation times are sufficiently well separated (uncoupled) we can again derive simplified expressions  

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