Chemical Properties and Reactions of Lactim Ethers

The reactions of lactim ethers involving the lactim ether part may be classified into two groups. 

Granik, Candidate s Dissertation, Moscow, Ordzhonikidze All-Union Chemical Pharmaceutical Scientific Research Institute, 1967. 

Cairns16 have mentioned a similar rearrangement of O-methyl(ethyl) caprolactims (2, R = Me and R = Et) to jV-methyl(ethyl) caprolactams (3, R = Me and R = Et), and a similar rearrangement takes place in 

The alkylation of markedly acidic substances by lactim ethers is a reaction of the first type. Lactim ethers have been used as alkylating agents for imino compounds such as uric acid (39), xanthines, and hypoxanthine,08 and for the esterification of organic acids.09 

Reactions of the second type, especially those involving amino derivatives and compounds with active methylene groups, give rise to promising methods of heterocyclic synthesis. 

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