Chemical lesions acidic substance

VITAMIN B2 (Riboflavin). Some earlier designations for this substance included vitamin G, lactoflavin, hepatoflavin, ovoflavin, veidoflavin. The chemical name is 6,7-dimcthyl-9-d-l ribityl isolloxazine. Riboflavin is a complex pigment with a green fluorescence. Riboflavin deficiency frequently accompanies pellagra and the typical lesions of both nicotinic acid and riboflavin deficiency are found in that disease. See also Niacin. 

In addition, another important property of some chemical agents is not only their capacity to cause skin lesions but also to be absorbed through the skin into the circulation and have general toxic effects on the patient including liver, kidney, and other vital organs of the body. Such chemical agents include phenols, cresols, chromic and formic acids, and other organic chemical substances. Extensive lesions from acids and alkalis may also lead to acidosis or alkalosis that will have to be treated. 

This pattern also applies to many of the chemical substances that act via nucleic acids. The repair processes used to eliminate primary lesions in DNA probably have the normal physiological rdle of maintaining the genome intact, in the face of continual insult. Cell injury may follow the blocking of these repair processes thereby allowing damage to accumulate. This may open a new approach for the elimination of a particidar cell type. It is already clear that frequently mutations induced by radiation, or by chemicals, are produced indirectly and that the altered base sequences which constitute the mutation are introduced by the cell itself during the process of repair of the primary lesions. 

---