Chemical imaging analysis

Figure 8.13 Chemical image analysis tools use domain morphology to highlight caffeine domains in the tablet.

Figure 8.14 (A-F) Chemical image analysis of six tablets composed of 80 mg of furosemide (API) mixed with...

Figure 7.10 Chemical image analysis of six tablets composed of 80 mg of furosemide (API) mixed with 240mg of the excipient mix (99.7% Avicel PH 102 and 0.33% magnesium stearate). Tablets A-E were created in the laboratory using increasing blending time, tablet F is an example of a commercial product. These PLS score images of the tablets highlight the location of the API component (bright pixels), and show the gross blend-quality differences.

Chemical Imaging Analysis of Heterogeneous Products and Heterogeneous Product Streams... 

Diamond, S., and Olek, "Cement Particle Characterization by SEM-Chemical Image Analysis Systems," Proceedings ofthe 12th International Conference on Cement Microscopy, International Cement Microscopy Association, Vancouver, British Columbia, 1990, pp. 356-369. 

Monnier, O., Fevotte, G., Hoff, C. and Klein, J.P., 1997. Model identification of batch cooling crystallizations through calorimetry and image analysis. Chemical Engineering Science, 52, 1125-1139. 

Valuable results with Tof-SIMS imaging have been obtained e.g., with paper samples. The distribution of papermaking chemicals on the surface of coated and uncoated papers is very important for its further treatment, such as printing. Figure 16 [70] is an example of use of the technique for chemical microscopy analysis of paper surfaces. 

Nevertheless, the introduction of time-of-flight (ToF) analysers for SIMS analyses at the beginning of the 1980s, as well as the recent development of liquid ion sources delivering cluster projectiles now permit the analysis of organic materials with high sensitivity and selectivity. Moreover, thanks to its excellent lateral resolution (in the order of micrometres), and its minimal sample preparation, ToF-SIMS has become the reference technique for chemical imaging by mass spectrometry. 

V. Mazel, P. Richardin, D. Touboul, A. Brunelle, P. Walter and O. Laprevote, Chemical imaging techniques for the analysis of complex mixtures new application to the characterization of ritual matters on African wooden statuettes, Analytica ChimicaActa, 570, 34 40 (2006). 

Scientific progress has resulted in the continual development and evolution of useful and powerful techniques, such as multiparameter flow cytometry and image analysis, to answer questions of cellular maintenance and function (and the impact chemicals may exert) for the benefit of human health. Multiparameter flow cytometry provides researchers with a capacity to simultaneously examine multiple cellular characteristics on thousands of cells in a relatively short period of time. 

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