Chemical dendritic molecule

FIGURE 5.42 Chemical structures of first-generation (42) and second-generation (43) self-immolative, receiver-amplifier dendritic molecules with an enzymatic trigger (blue), cleaved by PGA and 6-aminoquinoline (red) reporter groups. 

FIGURE 5.10 Chemical structures of AB3 self-immolative dendritic molecules with tryptophan tail units and a trigger that is activated by PGA. 

Undoubtedly, the chemistry of dendritic molecules has become more and more interesting and gained in importance as can be observed from an ever increasing number of publications on this topic in the chemical literature exceeding now 2000. 

Assemblage of the dendritic molecules by chemical crosslinking into an array, which is more or less organized. The specific functions of dendrimers can be possibly amplified when they are assembled into superstructures [65]. 

There is a space that exists between neurons known as the synapse. The transmission of the nerve signal across this synaptic cleft is a chemical phenomenon. Molecules generically referred to as neurotransmitters are produced in the neuron and released from the axonal membrane into the synapse. They diffuse to the dendrites of the next nerve cell and combine with receptors. This combination of neurotransmitter (agonist) and receptor produces a response which results in the propagation of the nerve signal down the next neuron. We will discuss this activity in much more detail shortly. 

These features of these materials spurred the scientific community to utilize them in biomedical applications [49]. In particular, the synergy between their multivalency and size on the nanoscale enables a chemical smartness along their molecular scaffold that achieves environmentally sensitive modalities. These functional materials are expected to revolutionize the existing therapeutic practice. Dendritic molecules, such as polyamidoamine, polylysine, polyester, polyglycerol (PG), and triazine dendrimers, have been introduced for biomedical applications to amplify or multiply molecularly pathopharmacological effects [73]. 

Bibliography and Notes for Chapter 6 (Special) chemical reactions of dendritic molecules I 247... 

The term dendritic effect has meanwhile become current usage for characterisation of generation-dependent physical and chemical phenomena in dendritic molecules. C. Valerio, J.-L. Fillaut, J. 

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