Chemical Connections Atom Economy

Design reactions with higher yields and better atom economy. See Chemical Connection 1.2.2.1 Yield versus Atom Economy. ... 

One of the drawbacks of DHAP aldolases is their strict specificity toward the donor substrate DHAP. DHAP is chemically unstable, particularly under alkaline conditions, and decomposes into inorganic phosphate and methyl glyoxal, both of which may inhibit the aldolase [4cj. Although the preparation [22] and synthetic applications of DHAP have reached a high degree of sophistication and efficiency [4h, 6e,i, 23], the preferred choice is by far the inexpensive unphosphorylated DHA nucleophile, which reduces costs and improves the atom economy of the process, especially when the phosphate group of the product must be removed in a separate reaction. In this connection, we focused our efforts on RhuA and FSA from E. coli [24]. 

The consideration of waste generation is of prime importance in green chemistry. In fact, as one designs new procedures and chemicals, it is appropriate to consider the production and disposition of waste as part of the design process. The consideration of atom economy for example, can highlight the production of waste more so than just considering percent yield. (See Chemical Connection 1.2.2.1.)... 

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