Chemical biology platforms

Managerial Challenges in Implementing Chemical Biology Platforms... 

In 2000, I introduced the Kinase Chemical Biology Platform that was the first of our four CBPs. The initial step was to identify all scientists across the company (now Aventis) with expertise and interest in kinases. The survey yielded about 300 scientists, many of whom were actively involved in kinase projects. We created a Kinase Community of Practice with these scientists as members and used knowledge mail to facilitate communication, exchange, and development of the kinase network. 

Shortly thereafter, a total of four chemical biology platforms kinase (CBK) led by Dr Andreas Batzer, protease (CBP) led by Dr Hans Peter Nestler, ion channels and transformers (CBICT) led by Dr Heiner Glombik, and G-protein coupled receptors (CBG) led by Dr Bruce Baron, were in operation. Thus, within 18 months of my describing CBPs in my keynote address at IBC Drug Discovery Conference in Boston in 2000, four CBPs were functioning. 

Another area in chemical biology that the triazole-forming click reactions have revolutionized is activity-based protein profiling (ABPP). ABPP is a chemical biology platform that uses active site-directed probes [61] to study the dymamic expression and function of mechanistically similar enzymes in their various... 

Pizzirani D, Robert M, Recanatini M (2007) Domino Knoevenagel/Diels-Alder sequence coupled to Suzuki reaction a valuable synthetic platform for chemical biology. Tetrahedron Lett 48 7120-7124... 

Design factors Monolithic screening Platform screening Chemical biology... 

Example HTS Platforms that Support Research in Chemical Biology... 

As a primer to this area, we outline the basic process of HTS and synergisms between pharmaceutical and chemical biology research endeavors and provide examples of platforms that use HTS technologies to enable chemical biology. 

Chemical Biology Global Platform - Kinase Discovery team 250-300... 

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