Channelopathies acquired

Horn I don t know whether you would call this an acquired channelopathy, but there was a recent paper from Reinhart Rudel s group in MS patients and patients with Guillain-Barre syndrome, about an endogenous pentapeptide that has biophysical effects on inactivation (Brinkmeier et al 2000). Do you know what isoform of Na channel they were looking at ... 

Horn If it holds up, would you call that, by definition, an acquired channelopathy ... 

Alterations in the structure or function of an ion channel caused by mutations in a gene encoding one of the channel s subunits are termed channelopathies. Initially, these abnormalities were associated with cardiac and muscular disorders, but today, it is recognized that channelopathies are responsible for several forms of epilepsy (15,16). Presently, most of the discovered channel mutations appear to be associated with the development of idiopathic generalized epilepsy most partial seizures are believed to be acquired. Minor alterations in gene structure or expression, however, may predispose a given individual to partial seizures. It is estimated that 40% of adult and childhood epilepsy may result from genetic factors. 

Bernard, C, Anderson, A, Becker, A, Poolos, NP, Beck, H, Johnston, D (2004) Acquired dendritic channelopathy in temporal lobe epilepsy. Science, 305 532-535. 

Waxman SG (2001) Acquired channelopathies in nerve injury and MS. Neurology 56 1621-1627... 

Choudhuri I, Pinninti M, Marwah MR, Sra J, Akhtar M (2013) Polymorphic ventricular tachycardia-part I structural heart disease and acquired causes. Curr Probl Cardiol 38 463-496 Choudhuri I, Pinninti M, Marwali MR, Sra J, Akhtar M (2013) Polymorphic ventricular tachycardia-part II the channelopathies. Curr Probl Cardiol 38 503-548 Cooper LB, DeVore AD, Michael Felker G (2015) The impact of worsening heart failure in the United States. Heart Fail Clin 11 603-614... 

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