Channel ,6 Subunit Antagonists

In the case of L-type Ca2+ channels, they also carry binding sites for Ca2+ antagonist drugs. The accessory a2-5, p, and y subunits stabilize Ca2+ channel function and support its targeting to the plasma membrane. Notably other proteins can associate with the channel complex allowing the formation of signaling complex important for channel targeting and modulation. 

ACh receptors are present in the post-junctional membrane of the endplate, in the junctional folds. The nicotinic ACh receptor at the motor endplate has five subunits, two os, (3, 5 and . In addition, a Y subunit instead of an e subunit may be present in the so-called extra-junctional or the fetal receptor. The five subunits are arranged as a cylinder around a central funnel-shaped pore, the ion channel. The two a subunits each carry a recognition site which binds nicotinic agonists such as ACh and antagonists such as the neuromuscular blocking agents. Whilst ACh must bind to both subunits to produce an effect, it is sufficient for... 

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