Ion channels as target

Bloomquist JR (1996) Ion channels as targets for insecticides. Annu Rev Entomol 41 163-190... 

Ion Channels As Targets For Drugs As major classes of pharmacological receptors ion channels are automatic loci for drug action. However, ion channels are particularly attractive targets for several additional reasons [ 4 ] ... 

Narahashi T (1996) Neuronal ion channels as the target sites of insecticides. Pharmacol Toxicol 79 1-14... 

Narahashi T. 1991. Transmitter-activated ion channels as the target of chemical agents. AdvExpMed Biol 287 61-72. 

All structures were selected from the Ensemble database. In addition to approved therapeutic agents these particularly include a set of lead compounds entered in advanced clinical/preclinical trials (a total of 16,540 compounds). Structures were extracted according to the assigned activity class, where the class indicates a common target-specific group such as GPCRs, kinases and proteases, nuclear receptors, and ion channels as well as more than 150 subclasses (for example, serotonin, tachykinin and dopamine receptors, tyrosine, Abl, Aurora and serine/threonine kinases, cysteine and serine proteases, etc.). Prior to the statistical experiments, the molecular structures should be filtered and normalized in order to fulfill certain criteria (see Subheading 3.5 and 4). 

B. Progress in the pharmacological control of membrane transporters Voltage-Gated Ion Channels as Drug Targets... 

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