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Channel-forming polypeptides, membrane potential

Most channels behave as simple resistors to current flow when the channel is open, the current through the channel varies linearly with membrane potential (AF — IR). The antibiotic polypeptide gramicidin A forms a cylindrical channel by end-to-end dimerization of two peptides, one in each of the bilayer leaflets. Individual gramicidin channels exhibit a resistance of 8 x 10 over... [Pg.132]

Alamethicin. The polypeptide alamethicin adds a level of complexity over gramicidin D. Like gramicidin D it forms cation channels through phospholipid bilayers. Unlike gramicidin D, alamethicin exhibits the voltage dependant gating which is characteristic of many protein ion channels. The alamethicin channel only transports cations when the membrane potential is greater than a threshold value (13). Conductance measurements of a phospholipid... [Pg.60]

See other pages where Channel-forming polypeptides, membrane potential is mentioned: [Pg.113]    [Pg.132]    [Pg.414]    [Pg.1723]    [Pg.403]    [Pg.368]    [Pg.89]    [Pg.414]    [Pg.683]    [Pg.244]    [Pg.114]    [Pg.223]    [Pg.5567]    [Pg.271]    [Pg.372]    [Pg.6]    [Pg.37]    [Pg.784]    [Pg.94]    [Pg.71]   
See also in sourсe #XX -- [ Pg.126 ]



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Membrane Form

Membrane channels

Membrane potential

Polypeptide membranes

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