Changes in cytoskeletal arrangement during neutrophil activation

5 Changes in cytoskeletal arrangement during neutrophil activation 

Early descriptions of the changes in cytoplasmic structure that occurred during pseudopodia formation referred to a soluble (Sol) and a gelled or semisolid (Gel) state. Thus, it was assumed that the cytoplasm in the organelle-free peripheral cytoplasm was in the Sol state, whilst in pseudopodia (which resist deformation by mechanical forces) it is in the Gel state. Thus, the control of neutrophil functions via changes in cytoplasmic structure may be explained by understanding this so-called Sol — Gel transition. It is perhaps more convenient to think of this transition as the processes that elongate and cross-link actin filaments. 

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