Challenges and examples

1 Tailoring drug delivery without additives through polyester acidic end groups 

Thin Film Coatings for Biomaterials and Biomedical Applications 

IPLGA 20 kDa ester terminus PLGA100 kDa ester terminus 

2 Tailoring material properties through oligomer additives while maintaining drug flux 

3 Example of how oligomer additives can achieve controlled drug flux 

---

Bruchet A, Hochereau C, Picard C, Decottignies V, Rodrigues JM, Janex-Habibi ML (2005) Analysis of drugs and personal care products in French source and drinking waters the analytical challenge and examples of application. Water Sci Technol 52 53-61... 

The history of these three lamp types offers as good an example as I know of the mechanism of challenge and response in industrial design. Several more major electric lamp types have been introduced during the past century - one of them will be outlined in the next section - but competition did not eliminate any of them. 

Example 2. Two-Shot Cast Elastomer (Prepolymer Method). Synthesis of polyurethane elastomers via the prepolymer method is challenging and requires especial attention to details and techniques. This example is a relatively easy one, using a low-viscosity, 9.6% NCO MDI-based poly(tetramethylene ether) glycol prepolymer. It is adapted from the Bayer Product Information Bulletin for Baytec ME-090 prepolymer. 

Thus far, we have only considered the angular geometry of complexes variations in bond lengths also pose challenges. For example, the gross inequality of bond lengths in [NiF ] and many copper(ii) and chromium(iii) complexes requires an explanation. Questions of this kind are also addressed in Chapter 7. 

The current undergraduate curriculum in chemical engineering, although it provides an excellent conceptual base for graduates who move into the electronics industries, could be improved by the introduction of instractional material and example problems relevant to the challenges outlined in this chapter. This would not require the creation of new courses, but rather the provision of material to emich existing ones. This theme is echoed, more broadly, in Chapter 10. 

These are just a few examples of what could go wrong with an NOE experiment. NOE experiments are not boring and all the same as a chemist acquaintance once famously remarked. Quite the contrary in fact. Designing sensible experiments to make use of the NOE and dovetailing the results with other NMR data, can be quite challenging - and rewarding when you finally pull all the threads together to produce a sensible picture of a problem molecule. 

---