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Shuffling chain

Marks, J D, Griffiths, A. D, Malmqvist, M, Clackson, T, Bye, J M, and Winter, G (1992) Bypassing immunization-building high-affinity human antibodies by chain shuffling. Biotechnology 10, 779-783. [Pg.459]

Kang, A S, Jones, T M, and Burton, D R. (1991) Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries Proc Natl Acad Sci USA 88, 11,120-11,123... [Pg.459]

This mutagenesis approach, in combination with light- and heavy-chain shuffling, is also the basis for the success in optimizing the affinity of an antibody directed towards... [Pg.228]

Waterhouse et al. (Ref. 65 Fig. 9B) first demonstrated the use of the CrdloxP in vivo site-specific recombination for chain shuffling (the procedure is described in the figure... [Pg.240]

Diversity in the antibody genes may be introduced using a variety of methods, which are either random or localized. Methods include using mutator strains [74,75], error-prone PCR [40], chain shuffling [32,76], and DNA shuffling [77],... [Pg.355]

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See also in sourсe #XX -- [ Pg.226 ]



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