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CGMP-dependent/independent mechanisms

MAHMA NONOate spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1 min at 37 °C. In vivo, examination in anesthetised rats showed, that MAHMA NONOate had both platelet inhibitory and vasodepressor effects [50]. Like other NONOates, MAHMA NONOate inhibited collagen-induced and ADP-induced rat platelet aggregation in a concentration-dependent manner [51]. ODQ, a soluble GS inhibitor, caused only small influence on the concentration-response curve to MAHMA NONOate, indicating that cGMP-independent mechanisms play a crucial role. A potential target of MAHMA NONOate induced inhibition was the sarco-endoplasmic reticulum calcium-ATPase of the platelet dense tubular system... [Pg.242]

See other pages where CGMP-dependent/independent mechanisms is mentioned: [Pg.168]    [Pg.234]    [Pg.243]    [Pg.316]    [Pg.529]    [Pg.532]    [Pg.536]    [Pg.283]    [Pg.118]    [Pg.914]    [Pg.98]    [Pg.254]    [Pg.413]    [Pg.74]    [Pg.170]    [Pg.857]    [Pg.209]    [Pg.857]    [Pg.141]    [Pg.86]   
See also in sourсe #XX -- [ Pg.170 ]



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CGMPs

Dependence mechanism

Dependent independent

Mechanics Dependency

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