Cystic fibrosis transmembrane cftr

The gene defective in cystic fibrosis codes for CFTR (cystic fibrosis transmembrane condnctance regulator), a membrane protein that pumps CP out of cells. If this CP pump is defective, CP ions remain in cells, which then take up water from the surrounding mucus by osmosis. The mucus thickens and accumulates in various organs, including the lungs, where its presence favors infections such as pneumonia. Left untreated, children with cystic fibrosis seldom survive past the age of 5 years. 

CFTR Cystic fibrosis transmembrane conductance regulator... 

CFTR (cystic fibrosis transmembrane conductance regulator) a membrane protein that functions as a chloride channel. 

The gene product is termed CFTR (cystic fibrosis transmembrane conductance regulator), and it codes for a chloride ion channel. It may also carry out additional (as yet undetermined) functions. 

Genetic testing for cystic fibrosis using PCR. CFTR = cystic fibrosis transmembrane regulator. 

CFTR = Cystic Fibrosis Transmembrane conductance Regulator... 

CFTR Cystic fibrosis transmembrane conductance regulator CHO Chinese hamster ovary cell line cmc Critical micelle concentration CPZ Chlorpromazine... 

CFTR cystic fibrosis transmembrane conductance regulator CGE capillary gel electrophoresis CHCA a-cyano-4-hydroxycinnamic acid CHO Chinese hamster ovary cells CL chemiluminescence... 

CDK2, cell division kinase 2 cDNA, complementary DNA CDP, cytidine 5 -diphosphate CDPK, Ca2+-dependent protein kinase, calmodulin domain protein kinase CFTR, cystic fibrosis transmembrane conductance regulator cGMP, 3, 5 -c.yclic guanosine monophosphate cGMP PDE, cyclic GMP phosphodiesterase... 

Lipecka, J., Norez, C., Bensalem, N., Baudouin-Legros, M., Planelles, G., Becq, F, Edelman, A., Davezac, N. Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin involvement of the keratin 18 network. J. Pharmacol. Exp. Then 2006, 317, 500-505. 

CFTR cystic fibrosis transmembrane regulator FEF25%-75% forced expiratory volume from 25 to 75% of vital capacity... 

CFTR Cystic fibrosis transmembrane conductance regulator a ligandgated chloride channel that is regulated by phosphorylation. It is a member of the adenine nucleotide binding cassette (ABC) family of transport proteins. 

Membrane transporters constitute a rather small family of drug targets. Some of them have yet to reveal their relevant therapeutic interest, that is, as targets of diuretics or antide-pressive drugs, but some others stiU resist to pharmacological control, that is, CFTR (Cystic Fibrosis Transmembrane conductance Regulator) for cystic fibrosis therapy and multidmg resistance transporter to improve cancer therapy. 

The primary structure refers to the amino acid sequence of the polypeptide chain. An error caused by a single incorrect amino acid amongst a chain of 1480 amino acids can seriously affect the function of the protein. This happens in people with cystic fibrosis who have a defective CFTR (cystic fibrosis transmembrane conductance regulator) gene, which produces a defective chloride transporter protein. In 70% of people with cystic fibrosis, the mutation is deletion of 3 base pairs in the DNA, which results in the loss of phenylalanine... 

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