Cervical squamous intraepithelial lesions

Ellerbrock TV, Chiasson MA, Bush TJ, Sun XW, Sawo D, Brudney K, et al. Incidence of cervical squamous intraepithelial lesions in HIV-infected women. JAMA 2000 283 1031-7. 

The main diagnostic roles for immunohistochemistry in evaluation of cervical squamous intraepithelial lesions (SIEs) are distinguishing dysplasia from benign mimics... 

McCluggage WG, Buhidma M, Tang L, et al. Monoclonal antibody MIBl in the assessment of cervical squamous intraepithelial lesions. Int J Gynecol Pathol. 1996 15 131-136. 

Shi J, Liu H, Wilkerson M, et al. Evaluation of pl6INK4a, minichromosome maintenance protein 2, DNA topoisomerase II alpha, ProEX C, and pl6INK4a/ProEX C in cervical squamous intraepithelial lesions. Hum Pathol. 2007 38 1335-1344. 

Guimaraes MG, Goncalves MA, Soares GP, et al. Immunohisto-chemical expression of pf 6INK4a and hcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions. J Histochem Cytochem. 2005 53 509-546. 

Coelho A, Matos A, Catarino R, et al. Protective role of the polymorphism CCR2-641 in the progression from squamous intraepithelial lesions to invasive cervical carcinoma. Gynecol Oncol 2005 96 760-764. 

FIGURE 18.6 MIBl is expressed variably in the mid and upper layers of cervical low-grade squamous intraepithelial lesion (A, B) and diffusely throughout the full thickness of cervical high-grade squamous intraepithelial lesion (C, D). 

Pirog EC, Baergen RN, Soslow RA, et al. Diagnostic Accuracy of Cervical Low-Grade Squamous Intraepithelial Lesions Is Improved With MIB-1 Immunostaining. Am J Surg Pathol. 2002 26 70-75. 

Kelly D, Kincaid E, Pansier Z, et al. Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProEx C). Cancer. 2006 108 494-500. 

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