Cerebral autosomal dominant leukoencephalopathy

Unlu M et al. Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry. Neurosci Lett 2000 282 149-152. 

Van den Boom R, Lesnik Oberstein SA, van Duinen SG, Bor-nebroek M, Ferrari MD, Haan J, van Buchem MA (2002) Subcortical lacunar lesions an MR imaging finding in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Radiology 224 791-796... 

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy... 

Jung HH, Bassetti C, Tournier-Lasserve E et al. (1995). Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy a clinicopathological... 

Sometimes arterial occlusion is demonstrated by angiography in migrainous stroke and the cause is hypothesized to be in-situ thrombosis complicating vasospasm. No provoking factors are known. Other possible causes of stroke in the context of headache must be considered carotid dissection, mitochondrial cytopathy, ruptured vascular malformation, antiphospholipid antibody syndrome and CADASIL (cerebral autosomal dominant arterio-pathy with subcortical infarcts and leukoencephalopathy). Migraine auras without headache may be confused with TIA (Ch. 8). 

Cerebral ischemic injury is a common cause of dementia in older adults. Combination cases of vascular dementia and Alzheimer disease are also quite frequent. Vascular causes of dementia include subcortical vascular dementia, multi-infarct dementia, ischemic dementia, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and leuko-araiosis (see the Cerebrovascular Diseases section earlier in this chapter). ... 

---