Cerebellum, concepts

Kaur C, Sivakumar V, Zhang Y, ling EA (2(X)6) Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum. Gha 54 826-839 Kim JH, Park JA, Lee SW, Kim WJ, Yu YS, Kim KW (2006) Blood-neural barrier intercellular communication at gUo-vascular interface. J Biochem Mol Biol 39 339-345 Kimelberg HK (1995) Current concepts of brain edema. Review of laboratory investigations. J Neurosurg 83 1051-1059... 

Schmahmann JD (1997) Rediscovery of and early concept. In The Cerebellum and Cognition (Schmahmann JD, ed), pp. 3-27. San Diego Academic Press. 

Haines DE, Dietrichs E (1987) On the organization of interconnections between the cerebellum and hypothalamus. In King JS (Ed.), New Concepts in Cerebellar Neurology and Neurobiology, Vol. 22. Liss, New York, 113-150. 

Voogd J, Hess DT (1989) Identification of A, X and B cortical zones and white matter compartments in the anterior vermis of the cerebellum of the monkey (Macaca fascicularis). Soc. Neurosci. Abstr, 15, 611. Voogd J, Hess DT, Marani E (1987a) The parasagittal zonation of the cerebellar cortex in cat and monkey. Topography, distribution of acetylcholinesterase and development. In King JS (Ed.), New Concepts in Cerebellar Neurobiology. Liss, New York, 183-220. 

This problem was addressed by refining analysis techniques to permit analysis of energy metabolites in small 20-80 mg brain samples (Schenker et al., 1966). This approach permitted analysis in cortex, subcortex, and cerebellum of ATP in symptomatic animals without inclusion in the kemicteric samples of normal tissue. Results showed a 13% depletion in the cerebellum of mildly symptomatic Gunn rats, and a 27% depletion of ATP in animals with advanced symptoms. Cortex and subcortex (nonstained) samples were unchanged. This supported the concept, based on symptomatology, and neuropathologic findings, that the toxicity of bilirubin in vivo is limited to the cerebral areas affected. 

Using these procedures, the postnatal blood levels of pups from dams exposed to lead at time of conception were found to be markedly elevated (45 fig lead/dl blood) between postnatal days 4-8 (Table 2). This corresponds with periods of extensive cell acquisition, particularly in the cerebellum which is completely formed postnatally (Jacobson, 1978). Subsequently the blood lead levels dramatically declined to 20jUg/dl by day 12 and then slowly increased to 40 jUg/dl at time of weaning (day 20). 

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