Cerbinal

The iridoids cerbinal, cerberic acid and cerberinic acid are found in the methanol extract of the bark of C. manghas [67]. The crude extract obtained by percolation from 4 kg of stem bark and 1.9 kg of root bark were diluted with water to 50% water methanol. The mixture was washed with hexane and partitioned with benzene. Benzene fractions were re-suspended in methanol and cerbinal (120 mg from stem bark extract and 300 mg from root bark extract) precipitated. 

The supernatant was chromatographed on a silica gel column and cerbinal, cerberic add and cerberinic add were eluted with benzene/acetone. 

Abe F, Okabe FI, Yamauchi T. Studies on Cerbera II. Cerbinal and its Derivatives, Yellow Pigments in the Bark of Cerbera manghas L.. Chemical Pharmaceutical Bulletin 1977 25(12) 3422-3424. 

Apart from these above mentioned compounds, courmains, iridoids, and alkaloids have also been obtained from semi-mangroves distributed in China. For example, cerbinal, p-hydroxy-benzaldehyde, benzamide, n-hexadecane acid monoglyceride, loliolide, 3-sitosterol, et al. 

---