Cephalosporins Theophylline

Isolated seizures that are not epilepsy can be caused by stroke, central nervous system trauma, central nervous system infections, metabolic disturbances (e.g., hyponatremia and hypoglycemia), and hypoxia. If these underlying causes of seizures are not corrected, they may lead to the development of recurrent seizures I or epilepsy. Medications can also cause seizures. Some drugs that are commonly associated with seizures include tramadol, bupropion, theophylline, some antidepressants, some antipsy-chotics, amphetamines, cocaine, imipenem, lithium, excessive doses of penicillins or cephalosporins, and sympathomimetics or stimulants. 

For a few drugs such as theophylline, saliva drug concentrations have been employed to supplement the collection of blood samples. However, the intersubject and intrasubject variability in saliva/plasma ratios have generally precluded the sole use of saliva drug concentrations to assess bioavailability. For some drugs such as cephalosporin antibiotics, clinical studies may also include a determination of appearance of drug in other body fluids such as the cerebrospinal fluid and bile. 

Fabre, H. Fell, A.F. Comparison of techniques for peak purity testing of cephalosporins. J.Liq.Chromatogr., 1992, 15, 3031-3043 [also theophylline]... 

Theophylline HPLC Acetazolamide cephalosporins endogenous xanthines and accumulated theophylline metabolites in renal failure (minor effect). 

The respective mixed-mode phase with cation-exchange properties is suitable for the analysis of a number of compound classes. The most important ones include alkaloids, water-soluble vitamins, sulfonamides, cephalosporins, catecholamines, diuretics, and xanthines, as well as a number of basic dyes. Figure 6.71 shows the separation of 10 different alkaloids, of which theophylline, theobromine, and caffeine are genuine constituents in beverages such as coffee and tea. In comparison to the classical separation on ODS phases, potentially interfering matrix components are better separated on a mixed-mode phase. 

Noninterfering amikacin, aztreonam, carbamazepine, cephalosporins, ciprofloxacin, clavulanic acid, difloxacin, digitoxin, digoxin, fleroxacin, fosfomycin, furosemide, gentamicin, imipenem, lidocaine, netilmicin, norfloxacin, ofloxacin, pefloxacin, penicillins, phenobarbital, phenytoin, primidone, procainamide, quinidine, rifampin, salicylic acid, teicoplanin, theophylline, tobramycin, valproic acid, vancomycin... 

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