Immunogenicity cephalosporin

Delafuente JC, Panush RS, Caldwell JR (1979) Penicillin and cephalosporin immunogenic-ity in man. Ann Allergy 43 337... 

Adverse effects Aztreonam is relatively nontoxic, but it may cause phlebitis, skin rash, and occasionally, abnormal liver function tests. Aztreonam has a low immunogenic potential and shows little cross-reactivity with antibodies induced by other p-lac-tams. Thus aztreonam may offer a safe alternative for treating patients allergic to penicillins and/or cephalosporins. 

Table 2. Immunogenicity of penicillins and cephalosporins in guinea pigs ...

In man, allergic reactions have been in reported in patients with no prior history of penicillin allergy, leading to the assumption that cephalosporins may be immunogenic by themselves (Kaplan and Weinstein 1967 Abraham et al. 1968 a, b Molthan 1969 Saleh and Tischler 1974). 

Batchelor FR, Dewdney JM, Weston RD, Wheeler AW (1966) The immunogenicity of cephalosporin derivatives and their cross reaction with penicillin. Immunology 10 21 Batchelor FR, Dewdney JM, Feinberg JG, Weston RD (1967) A penicilloylated protein impurity as a source of allergy to benzyl penicillin and 6-aminopenicillanic acid. Lancet 1 1175... 

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