Cephalosporins allergy aminolysis

Bundgaard H (1974) Spectrophotometric determination of ampicillin sodium in the presence of its degradation and polymerization products. J Pharm Pharmacol 26 385 Bundgaard H (1975) Chemical studies related to cephalosporin allergy. I. Kinetics of aminolysis of cephalosporins and effect of C-3 substituents on beta-lactam reactivity. Arch Pharm 3 94... 

Penicillins and cephalosporins bind irreversibly to serum albumin. It has been shown that drug-protein conjugates result from the aminolysis of the /3-lactam bond by the e-amino group of lysine residues in the protein (Fig. 5.1, Pathway e). The bound penicilloyl group appears to be the major antigenic determinant of penicillin allergy [145-148],... 

Gutzwiller P (1974) Zum Problem der Kortikosteroid-Allergie. Dermatologica 148 253-256 Hamilton-Miller JMT, Newton GGF, Abraham EP (1970) Products of aminolysis and enzymic hydrolysis of the cephalosporins. Biochem J 116 371-384 Hertz CG (1973) The low incidence of side effects with cyclacillin. Arzneim Forsch [Suppl] 25 151-156... 

Studies on the chemical aspects of penicillin allergy have shown that the penicilloyl determinant in penicillin allergy can be formed by the reaction of benzylpenicillenic acid with free functional groups in proteins, Benzylpenicillenic acid can react with SH groups of protein to form thio-esters similar to its reaction with amino groups to form amides a. Products obtained in aminolysis and enzymic hydrolysis of cephalosporins... 

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