Central dogma of molecular

The original Central Dogma of molecular biology (left) and its modification in light of the discovery of viruses (right). 

What Crick called the "central dogma of molecular genetics" says that the function of DNA is to store information and pass it on to RNA. The function of... 

Sarkar, S. (1996a), Biological information a skeptical look at some central dogmas of molecular biology , in S. Sarkar (Ed.), The Philosophy and History of Molecular Biology New Perspectives, Kluwer, Dordrecht, The Netherlands, pp. 187-231... 

The central dogma of molecular biology and protein synthesis... 

Francis Crick enunciated the central dogma of molecular biology in 1958 DNA directs its own replication and its transcription to RNA that, in turn, directs its translation to protein. This statement is frequently oversimplified to DNA makes RNA makes protein. ... 

The central dogma of molecular biology was first defined by Francis Crick. See R. Olby, Francis Crick, DNA, and the Central Dogma . Daedalus Fall 1970, pp 970-986. 

Figure 20.18 The central dogma of molecular biology a summary of processes involved inflow of genetic information from DNA to protein. The diagram is a summary of the biochemical processes involved in the flow of genetic information from DNA to protein via RNA intermediates. This concept had to be revised following the discovery of the enzyme, reverse transcriptase, which catalyses information transfer from RNA to DNA (see Chapter 18). It may have to be modified in the future since changes in the fatty acid composition of phospholipids in membranes can modily the properties of proteins, and possibly their functions, independent of the genetic information within the amino acid sequence of the protein (See Chapters 7, 11 and 14).

As the field of molecular genetics grew, the DNA molecule became the focus of many research efforts. Francis Crick and George Gamov developed the sequence hypothesis to explain how DNA makes protein. They stated that the DNA sequence specifies the amino acid sequence of a protein and postulated the central dogma of molecular genetics the flow of genetic information is a one-way road, it always takes the direction from DNA to RNA to protein [16]. In the same year, 1957, Mathew Meselson and Frank Stahl demonstrated the replication mechanism of DNA [17]. In 1958, DNA polymerase became the first enzyme used to make DNA in a test tube. 

The structure of DNA/RNA enabled Crick to formulate the central dogma of molecular genetics. By this dogma, three fundamental processes take place in the transfer of genetic information. Replication is the process by which identical copies of DNA are made so that information can be preserved and transferred from generation to generation. 

The central dogma of molecular biology, showing the general pathways of information flow via replication, transcription, and translation. The term "dogma" is a misnomer. Introduced by Francis Crick at a time when little evidence supported these ideas, the dogma has become a well-established principle. 

The central dogma of molecular genetics The central dogma was based upon the findings of Watson and Crick and states that the flow of information is essentially in one direction from DNA to protein. Three major steps can be defined in the process replication, transcription and translation of genetic material, as shown in Fig. 5.A9. 

Since then some progress has been made in this direction (completely independently of Ya.B. ) in violation of the central dogma of molecular genetics, influence of transport RNA on DNA was discovered. It is possible that the ideas of how reacting substances influence enzymes will prove significant in the study of the prebiological stage of evolution. 

Crick, F., Central dogma of molecular biology. Nature 227 561-563, 1970. 

Most RNAs function in an information carrying and/or processing mode in the cell. As Chapter 4 of Volume 1 of this series pointed out, the overall information processes of the cell are given in the Central Dogma of Molecular Biology DNA makes RNA makes Protein. RNA is involved as a carrier of information, as translator or adaptor of RNA information into protein information, and as catalyst for the synthesis of the peptide bond. 

Crick, F.H.C. 1970. Central Dogma of molecular biology. Nature, 227, 561-563. 

Crick, F. H. C. (1970). Central dogma of molecular biology. Nature, 227, 561-563. DeGroot, M. H. (1970). Optimal Statistical Decisions. McGraw-Hill, New York. 

The central dogma of molecular biology describes how one form of biological information (an organism s genetic sequence) is processed in terms of DNA replication, RNA transcription, and protein synthesis. However, a related mystery is yet to be worked out in sufficient detail how is the information encoded in the DNA (i.e., genotypes) related to cellular functions (i.e., phenotypes) How do different signals tell different cells to synthesize different proteins ... 

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