Central composite designs chromatography

A combination of reversed-phase chromatography and ETAAS was proposed. A central composite design studied the chromatographic conditions. Response curves were deployed for each analyte in order to select the best experimental conditions and evaluate robustness... 

Do, B. et al. Application of central composite designs for optimisation of the chromatographic separation of monomethylarsonate and dimethylarsinate and of selenomethionine and selenite by ion-pair chromatography coupled with plasma mass spectrometric detection. AnaZy f 2001, 126, 594—601. 

Occasionally c = 1 is selected which creates a so-called face-centred central composite design. An alternative to the central composite designs, which, as far as we know, has not been used in chromatography, is the Box-Behnken 52) design. 

Owens PK, Fell AF, Coleman M, Berridge JC. Method development in liquid chromatography with a charged cyclodextrin additive for chiral resolution of rac-amlodipine utilizing a central composite design. Chirality 1996 8(7) 466-476. 

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