Synthetase cellulose

Oxidation of DNA, pyrimidines, and purines Inhibition of polysaccharide synthesis Oxidation of indoleacetic acid Inhibition of cellulose synthetase, phospho-glucomutase, UDPG pyrophosphorylase... 

Previously, this enzyme and the one that utilizes UDP-glucose have been designated as cellulose synthetases (EC 2.4.1.29 and EC 2.4.1.12, respectively). These designations should still be considered questionable. 

From the preceding discussions, it is evident that, in all systems studied, and, in particular, in higher plants, attempts to synthesize cellulose in vitro have met with only limited success this therefore leads to the conclusion that, for poorly understood reasons, the cellulose synthetase complex is a highly labile system. As a conclusion to this article, it may prove useful for future research to discuss possible reasons for this apparent lability. 

Several possible mechanisms can be envisaged to explain how Atjt may modulate the activity of the cellulose-synthetase complex. The effects of membrane fluidity on membrane-bound enzymes is well... 

Many difficulties have been encountered in the study of the biosynthesis of cellulose, chief among them being the apparent lability of the cellulose-synthetase system. Based on evidence accumulated to date, a current model of cellulose synthesis184 can be envisaged as indicated in Fig. 6. 

Herth W. 1989. Inhibitor effects on putative cellulose synthetase complexes of vascular plants. In Schuerch C. (ed.) Cellulose and Wood Chemistry and Technology. Wiley, New York, pp. 795-810. 

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