Cell volume, regulation

Small Cl -channels appear to play a pivotal role in cell volume regulation and in exocytosis in general. The existence of these channels has been difficult to prove, and it is only recently that they have been identified in very many cells. 

Cell-volume regulation involves control of the content of osmotically active impermeant molecules and ions 88... 

Sardini, A., Amey, J. S., Weylandt, K.-H., Nobles, M., Valverde, M. A. and Higgins, C. F. Cell volume regulation and swelling-activated chloride channels. Biochim. Biophys. Acta 1618 153- 162, 2003. 

Krane CM, Melvin JE, Nguyen HV, Richardson L, Towne JE, Doetschman T, Menon AG (2001) Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem 276 23413-23420... 

Okada, Y. and Maeno, E., 2001, Apoptosis, cell volume regulation and volume-regulatory chloride channels. Comp Biochem Physiol A Mol Integr Physiol 130, 377-83. 

Waldegger, S., Matskevitch, J., Busch, G.L. et al. Introduction to cell volume regulatory mechanisms, in Cell Volume Regulation, Lang, F. ed., Vol. 123. Basel Karger, 1998 pp. 1-7. 

Wehner, F., Olsen, H., Tinel, H. et al. Cell volume regulation osmolytes, osmolyte transport, and signal transduction. Rev. Physiol. Biochem. Pharmacol. 2003 148 1-80 (Epub 2003 Apr 4). 

Graf, J., Haddad, P., Haussinger, D., Lang, F. (1988). Cell volume regulation in liver. Renal Physiol. Biochem. 11,202-220. 

Hoffmann, E.K., Simonsen, L.O., Lambert, I.H. (1993). Cell volume regulation Intracellular transmission. In Interactions of Cell Volume and Cell Function (Lang, F. Haussinger, eds.), pp. 187-248, Springer-Verlag, Heidelberg. 

Lang, F., Stehle, T., Haussinger, D. (1989). Water, H+, lactate and glucose fluxes during cell volume regulation in perfused rat liver. Pfliigers Arch. Physiol. 413,209-216. 

McCarty, N.A. O Neil, R.G. (1992). Calcium signaling in cell volume regulation. Physiol. Rev. 72, 1037-1061. 

Chamberlin, M.E. Strange, K. (1989). Anisosmotic cell volume regulation A comparative view. Am. J. Physiol. 257, C159-C173. 

Somero, G.N., and P.H. Yancey (1997). Osmolytes and cell volume regulation physiological and evolutionary principles. In Handbook of Physiology, Section 14. Cell Physiology. Vol. II, pp. 1445-1477, ed. W. Danztler. New York Oxford. 

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