Cell/tissue culture constraints

Recently, a hypothesis based on inhibition of cell-to-cell communication has received considerable attention. According to this concept, neoplastic cells are normally restrained by interactions with normal cells and disruption of these exchanges would thereby release dormant neoplastic cells from tissue constraints allowing them to proliferate according to the altered genome (78,79). In support of this hypothesis, a variety of promotors have now been shown to produce inhibition of molecular transfer in culture (78,80-85). 

---